Dr Rackham is an expert in the development of computational approaches for cell reprogramming and disease-gene association. His group works on ways to identify key regulators that can control cell fate in order to find novel routes for cell conversion, as well as identifying drug targets to develop new cell therapies and pharmacological treatments for human disease. He has extensive expertise in the analysis of high-throughput sequencing data, biological network analysis and statistics. He completed his PhD in complexity sciences in 212, after which he became an MRC career development fellow at Imperial College London. In 215 he moved to Duke-NUS Medical School as a senior research fellow and subsequently started his own group in 216 focusing on data-driven tools for cell reprogramming and disease.

Dr Rackham has published 37 papers, has been cited over 35 times and has an h-index of 19. His work has been the focus of patent applications, and he has founded a spin-out company Mogrify, which operates in both Australia and the UK. He is also an active member of several international consortium including the FANTOM consortium and the Human Cell Atlas.