Dr Quan Nguyen is a Group Leader of the Genomics and Machine Learning Lab at QIMR Berghofer, with a joint appointment at the Institute for Molecular Bioscience of the University of Queensland. He acquired multidisciplinary expertise at the world’s top innovative institutions in Australia (UQ, CSIRO) and internationally (RIKEN Institute and Stanford School of Medicine). With supports from multiple prestigious fellowships, including ARC DECRA and NHMRC (EL2), he established his leadership in addressing cancer complexity at single cell and tissue levels. Dr Nguyen has led multiple large-scale projects/programs, funded nationally (e.g., ARC, NHMRC, MRFF) and internationally (e.g., DoD, NCI, Wellcome Trust). Using machine learning and genomic approaches, his group are integrating single-cell spatiotemporal sequencing data with tissue imaging data to find causal links between cellular genotypes, tissue microenvironment, and disease phenotypes. The lab is also developing experimental technologies that enable large-scale profiling of spatial gene and protein expression (spatial omics) in a range of cancer tissues (focusing on brain and skin cancer) and in mouse brain and spinal cord.